Frequency of Gilbert's syndrome associated with UGTA1 (TA)(7) polymorphism in Southern Italy.

site-specific T-lymphocytes release high levels of gamma interferon, which is required to activate and synergize macrophages for toxoplasmacidal activity.5 Therefore, delayed immune reconstitution after transplantation puts patients at risk of reactivation of latent infection. The precise kinetics of immune reconstitution after CD34+ cell-selected PBSCT are unknown, however, substantial T-lymphocyte defects and consequent increased incidence of opportunistic infection have been reported. In our case, it is likely that the combination of CD34+ cell-selected PBSCT and TBI regimen resulted in a further-delayed immune-cell reconstitution and rendered the patient susceptible to disseminated toxoplasmosis. Although more studies need to be done to improve the understanding of immunologic impairment responsible for toxoplasmosis reactivation, prophylactic therapy for toxoplasmosis could be beneficial for seropositive patients especially in cases of CD34+ positive selected transplantation with TBI regimen.